Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 42, Issue -, Pages 622-628Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2014.06.013
Keywords
Polyacrylamide; Alginate; Hydrogel; Mesenchymal stem cell; Proliferation; Chondrogenesis
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Funding
- National Institute on Deafness and other Communicative Disorders (from the NSFC grant) [81028003/H1305, 30973303]
- National Institute on Deafness and other Communicative Disorders (from the Key Basic Research Project of Shanghai Committee of Science and Technology) [10JC1402500]
- National Institute on Deafness and other Communicative Disorders (from the Ministry of Education grant) [20090071120072]
- National Institute on Deafness and other Communicative Disorders (from the Innovation Program of Shanghai Committee of Science and Technology) [11411952300]
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We describe the development of alginate/polyacrylamide (ALG/PAAm) porous hydrogels based on interpenetrating polymer network structure for human mesenchymal stem cell proliferation and chondrogenesis. Three ALG/PAAm hydrogels at molar ratios of 10/90,20/80, and 30/70 were prepared and characterized with enhanced elastic and rubbery mechanical properties, which are similar to native human cartilage tissues. Their elasticity and swelling properties were also studied under different physiological pH conditions. Finally, in vitro tests demonstrated that human mesenchymal stem cells could proliferate on the as-synthesized hydrogels with improved alkaline phosphatase activities. These results suggest that ALG/PAAm hydrogels may be a promising biomaterial for cartilage tissue engineering. (C) 2014 Elsevier B.V. All rights reserved.
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