Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 35, Issue -, Pages 106-114Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2013.10.015
Keywords
Bioceramics; Substituted hydroxyapatite; Aqueous precipitation; Simulated body fluid; Osteoblasts
Categories
Funding
- Warwick Chancellor's scholarship
- EPSRC [EP/L020815/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/L020815/1] Funding Source: researchfish
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Hydroxyapatite (HA) substituted with 2 mol% Sr, 10 mol% Mg, and 2 mol% Zn were precipitated under identical alkaline conditions (pH 11) at 20 degrees C from an aqueous solution. As-synthesised materials were confirmed to be phase pure by XRD and samples prepared in air contained surface adsorbed CO2 as observed by FTIR. SEM studies revealed a globular morphology and agglomeration behaviour, typical of precipitated nHA. EDS spectra confirmed nominal compositions and substitution of Sr, Mg and Zn. At the levels investigated cationic doping was not found to radically influence particle morphology. An indication of the potential in-vivo bioactivity of samples was achieved by analysing samples immersed in SBF for up to 28 days by interferometry and complementary SEM micrographs. Furthermore, a live/dead assay was used and confirmed the viability of seeded MC3T3 osteoblast precursor cells on HA and substituted HA substrates up to 7 days of culture. (C) 2013 Elsevier B.V. All rights reserved.
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