Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 36, Issue -, Pages 146-151Publisher
ELSEVIER
DOI: 10.1016/j.msec.2013.11.042
Keywords
Antibacterial agent; Soap-free emulsion polymerization; Silver; Nanocomposites
Categories
Funding
- Special Program for Key Research of Chinese National Basic Research Program [2011CB612303]
- Nation Natural Science Foundation of China [51173153, U1205113]
- Xiamen Science and Technology Committee [3502Z20120015]
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A simple method for preparing a new type of stable antibacterial agent was presented. Monodisperse poly(styrene-co-acrylic acid) (PSA) nanospheres, serving as matrices, were synthesized via soap-free emulsion polymerization. Field-emission scanning electron microscopy micrographs indicated that PSA nanospheres have interesting surface microstructures and well-controlled particle size distributions. Silver-loaded poly(styrene-co-acrylic acid) (PSA/Ag-NPs) nanocomposites were prepared in situ through interfacial reduction of silver nitrate with sodium borohydride, and further characterized by transmission electron microscopy and X-ray diffraction. Their effects on antibacterial activity including inhibition zone, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and bactericidal kinetics were evaluated. In the tests, PSA/Ag-NPs nanocomposites showed excellent antibacterial activity against both gram-positive Staphylococcus aureus and gram-negative Escherichia coli. These nanocomposites are considered to have potential application in antibacterial coatings on biomedical devices to reduce nosocomial infection rates. (C) 2013 Elsevier B.V. All rights reserved.
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