Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 39, Issue -, Pages 325-329Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2014.03.017
Keywords
Bulk metallic glass; Antimicrobial behavior; Copper
Categories
Funding
- US National Science Foundation (NSF) [CMMI-1100080]
- National Natural Science Foundation of China [51161130526]
- Office of Research and Engagement at the University of Tennessee
- NSF [DMR-0909037, CMMI-0900271]
- Department of Energy (DOE), Office of Energy's Nuclear Energy University Program (NEUP) [00119262]
- DOE, Office of Fossil Energy
- National Energy Technology Laboratory [DE-FE-0008855, DE-FE-0011194]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1100080] Funding Source: National Science Foundation
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The antimicrobial behavior of Cu-bearing Zr-based bulk metallic glasses (BMGs) was investigated for the first time against the Gram positive bacterium Staphylococcus aureus to evaluate their potential applications in healthcare settings. Despite their lack of bacteria-killing effect under a relatively severe experimental setting of dynamic immersion, the biocidal potency of the two Zr-based BMGs was demonstrated via a moist contact assay. There was a significant reduction in viable bacterial populations after 4 h of contact on the Zr-based BMGs, which was evidenced by the pronounced reduction in viable bacterial populations. To understand the mechanism of cell death, a direct relationship was established between the killing efficiency and the ability of the substrate to release Cu ions. Findings in this study will direct the future design of antimicrobial BMGs with enhanced killing efficacy. Published by Elsevier B.V.
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