Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 36, Issue -, Pages 287-293Publisher
ELSEVIER
DOI: 10.1016/j.msec.2013.12.025
Keywords
Oxidized hyaluronic acid; Casein protein; Gelation; Drug delivery; Biocompatibility
Categories
Funding
- National Natural Science Foundation of China [21074152, 51273216, 11103305]
- Doctoral Research Program of Education Ministry in China [20090171110023]
- Key Project of Scientific and Technical Innovation for Universities in Guangdong Province [cxzd1102]
- National Natural Science Foundation of Guangdong Province in China [S2013010012549]
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To develop biocompatible polymeric hydrogels for the in-situ encapsulation and controlled release of hydrophilic drugs, the oxidized hyaluronic acid containing aldehyde groups was prepared by the reaction between hyaluronic acid and sodium periodate, and then used for the first time to crosslink casein protein in aqueous system. By changing its aldehyde group content or amount, we found that the gelation kinetics and the properties of resultant composite hydrogel could be modulated. Particularly, an increase of its aldehyde group content or amount was found to result in a shorten gelation time, an enhanced gel strength, a reduced swelling ratio and a prolonged drug release. In addition, the as obtained composite hydrogel was also evaluated for its in vitro cytotoxicity on L929 mouse fibroblast cells and was confirmed to have a good biocompatibility. (C) 2013 Elsevier B.V. All rights reserved.
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