Construction of a non-enzymatic glucose sensor based on copolymer P4VP-co-PAN and Fe2O3 nanoparticles

An electrochemical sensor based on a copolymer poly(4-vinylpyridine)-co-poly(acrylonitrile), P4VP-co-PAN, and Fe2O3 nanoparticle film modified glassy carbon electrode was developed for the determination of glucose. We studied the response of glucose with the proposed electrode, and determined the optimum conditions by changing the potential, pH and P4VP-co-PAN. The current response measurements were performed in PBS (c = 0.1 M) with a potential of 0.7 V. The current response of this glucose sensor showed a linear relationship with the concentration in the range of 2.5 mu M-0.58 mM (r = 0.997). The experimental results demonstrate that this method has such merits as simple operation, low cost, high sensitivity, long term stability and good reproducibility, with satisfactory results. (C) 2013 Elsevier B.V. All rights reserved.