Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 43, Issue -, Pages 622-629Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2014.07.067
Keywords
Amoxicillin; Poly(methacrylic acid); Nanogel; Sustained release; Cytotoxicity; Long-term activity
Categories
Funding
- National Natural Science Foundation of China [81260406]
- Specialized Research Fund for the Doctoral Program of Higher Education Funding Issue [20114433110001]
- China Postdoctoral Science Foundation [2014M552217]
- Zhejiang Provincial Natural Science Foundation of China [LQ12E03005]
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In order to control the release of amoxycillin (AM) with lower cytotoxicity and higher activity, ethylene glycol dimethacrylate was used as the cross-linker, and a series of poly( methacrylic acid) (PMAA) nanogels were prepared to load the AM. Then, the morphology, size, in vitro release property, long-term antibacterial performance, cytotoxicity, stability and activity of this novel AM/PMAA nanogel were investigated. The results showed that the AM/PMAA nanogel sustainably released AM with long-term antibacterial activity. Moreover, the AM/PMAA nanogel could improve the stability of AM. More importantly, this AM/PMAA nanogel showed slighter cytotoxicity than AM alone, suggesting that the AM/PMAA nanogel was a more useful dosage form than AM for infectious diseases. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved,
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