Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 44, Issue -, Pages 326-335Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2014.08.020
Keywords
Calcium phosphate cement; Bone regeneration; Cellulose; Bone morphogenetic protein-2
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Funding
- National Basic Research Program of China (973 Program) [2012CB933600]
- National Natural Science Foundation of China [31271011, 31330028]
- National Science and Technology Support Program [2012BAI17B02]
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Large osseous defects remain a difficult clinical problem in orthopedic surgery owing to the limited effective therapeutic options, and bone morphogenetic protein-2 (BMP-2) is useful for its potent osteoinductive properties in bone regeneration. Here we build a strategy to achieve prolonged duration time and help inducting new bone formation by using water-soluble polymers as a protective film. In this study, calcium phosphate cement (CPC) scaffolds were prepared as the matrix and combined with sodium carboxymethyl cellulose (CMC-Na), hydroxypropylmethyl cellulose (HPMC), and polyvinyl alcohol (PVA) respectively to protect from the digestion of rhBMP-2. After being implanted in the mouse thigh muscles, the surface-modified composite scaffolds evidently induced ectopic bone formation. In addition, we further evaluated the in vivo effects of surface-modified scaffolds in a rabbit radius critical defect by radiography, three dimensional micro-computed tomographic (mu CT) imaging, synchrotron radiation-based micro-computed tomographic (SR mu CT) imaging, histological analysis, and biomechanical measurement. The HPMC-modified CPC scaffold was regarded as the best combination for segmental bone regeneration in rabbit radius, (C) 2014 Elsevier B.V. All rights reserved.
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