Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 33, Issue 8, Pages 4562-4567Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2013.07.009
Keywords
Oral drug delivery; High loading capacity; pH-sensitive; Nanoparticles; Electrospray; Cytotoxicity
Categories
Funding
- National Natural Science Foundation of China [31200713]
- International Science and Technology Cooperation Base Construction of Chongqing [CSTC 201110005]
- Chongqing University Postgraduates' Innovative Team Building Project [201105A1001]
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Drug loading capacity is an important property for an ideal drug delivery system. However, the drug loading capacity of prepared pH-sensitive polymeric nanoparticles is usually low. To overcome this drawback, the electrospray method was used to prepare Eudragit L 100-55 nanoparticles with high drug loading capacity in one step. Omeprazole was selected as the model drug. The maximum loading capacity of nanoparticles was 43.21% by changing the mass ratio of drug to polymer, and the entrapment efficiency was nearly 100%. The prepared nanoparticle showed spherical or ellipsoidal morphology and the average diameter was about 300 nm. The pH-sensitive nanoparticle displayed pH-dependent release in vitro. In addition, a slight cytotoxicity was detected in the cytotoxicity study. The results indicated that electrospray is an easy, rapid and efficient technique for the preparation of high-loading pH-sensitive polymeric nanoparticles, and the pH-sensitive nanoparticle is a promising carrier for oral drug delivery. (C) 2013 Elsevier B.V. All rights reserved.
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