Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 33, Issue 1, Pages 298-303Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2012.08.043
Keywords
Magnetic nanoparticles; Gold nanoparticles; Conductometric biosensor; Polyelectrolyte; Glucose oxidase
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Funding
- EGIDE through UTIQUE program [09G 1128, 10G1103]
- EGIDE through PHC Maghreb [14]
- Ministry of Education in Tunisia
- Agence Universitaire de la Francophonie (AUF) [6313PS025]
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The aim of this study was to show the feasibility and the performances of nanoparticle biosensing. A glucose conductometric biosensor was developed using two types of nanoparticles (gold and magnetic), glucose oxidase (GOD) being adsorbed on PAH (poly(allylamine hydrochloride)) modified nanoparticles, deposited on a planar interdigitated electrode (IDES). The best sensitivities for glucose detection were obtained with magnetic nanoparticles (70 mu M/mM and 3 mu M of detection limit) compared to 45 mu M/mM and 9 mu M with gold nanoparticles and 30 mu M/mM and 50 mu M with GOD directly cross-linked on IDEs. When stored in phosphate buffer (20 mM, pH 7.3) at 4 degrees C, the biosensor showed good stability for more than 12 days. (C) 2012 Elsevier B.V. All rights reserved.
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