Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 33, Issue 3, Pages 1022-1031Publisher
ELSEVIER
DOI: 10.1016/j.msec.2012.10.009
Keywords
Iron foam; Electrophoretic deposition; Calcium phosphate coating; Bioactive property
Categories
Funding
- Natural Science Foundation of China [51042012, 51272058]
- Hospital Foundation of First Affiliated Hospital of Harbin Medical University [YG2009MS53]
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Slow corrosion rate and poor bioactivity restrict iron-based implants in biomedical application. In this study, we design a new iron-foam-based calcium phosphate/chitosan coating biodegradable composites offering a priority mechanical and bioactive property for bone tissue engineering through electrophoretic deposition (EPD) followed by a conversion process into a phosphate buffer solution (PBS). Tensile test results showed that the mechanical property of iron foam could be regulated through altering the construction of polyurethane foam. The priority coatings were deposited from 40% nano hydroxyapatite (nHA)/ethanol suspension mixed with 60% nHA/chitosan-acetic acid aqueous solution. In vitro immersion test showed that oxidation-iron foam as the matrix decreased the amount of iron implanted and had not influence on the bioactivity of this implant, obviously. So, this method could also be a promising method for the preparation of a new calcium phosphate/chitosan coating on foam construction. (C) 2012 Published by Elsevier B.V.
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