Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 33, Issue 4, Pages 2399-2406Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2013.02.008
Keywords
Transition metal ions; Collagen; Hydroxyapatite; Mineralization; Collagen sponge
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Funding
- National Natural Science Foundation of China [20763009]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
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The ions in body fluid play an important role in bone formation besides being a synthesizing material. Transition metal ions Co2+, Ni2+, Zn2+, Fe3+, Mn2+, Cu2+, Cd2+ and Hg2+ doped hydroxyapatite (HAP)/collagen composites were synthesized successfully in the presence of collagen traces at mild acidic pH for the first time. However, the amount of doped Hg2+ and Cd2+ was relatively low. Meanwhile, through soaking the collagen sponge as a template in simulated body fluid (SBF) which contains different transition metal ions (Mn2+, Cu2+, Ni2+, Co2+, Cd2+, Hg2+), bone-like HAP/collagen composites were synthesized. Hg2+ had a certain inhibitory effect on the formation of HAP crystals on the surface of the collagen sponge while Co2+ can promote the formation of HAP on the collagen sponge. For both HAP/collagen composites and HAP/collagen sponge, it was found that transition metal ions Mn2+ had a significant effect on the morphology of HAP particles and could induce to form floc-like HAP particle aggregates. (C) 2013 Elsevier B.V. All rights reserved.
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