Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 33, Issue 5, Pages 2723-2735Publisher
ELSEVIER
DOI: 10.1016/j.msec.2013.02.039
Keywords
Electrospinning; Gelatin; Nanofibres; Aqueous solution; Glial cells
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Funding
- Regione Piemonte (Bando Ricerca Sanitaria Finalizzata)
- Compagnia San Paolo (MOVAG Project)
- CRT-Lagrange Project
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Gelatin (GL) nanofibrous matrices mimicking the complex biological structure of the natural extracellular matrix (ECM) were prepared from aqueous solutions by electrospinning technique. GL nanofibres with a diameter size of around 300 nm were obtained optimising the process and solution parameters. To increase the GL stability in aqueous environment gamma-glycidoxypropyltrimethoxysilane (GPTMS) was used as GL crosslinker. GPTMS crosslinking did not modify the nanofibrous matrix morphology: fibre diameter and membrane pores size were 327 +/- 45 nm and 1.64 +/- 0.371 mu m, respectively. The produced GPTMS crosslinked GL nanofibres (GL/GPTMS_NF) were found to support the in vitro adhesion, proliferation and survival of neonatal olfactory bulb ensheating cells (NOBECs). (C) 2013 Elsevier B.V. All rights reserved.
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