Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 33, Issue 1, Pages 519-526Publisher
ELSEVIER
DOI: 10.1016/j.msec.2012.09.024
Keywords
Atom transfer radical polymerization (ATRP); Calix[4]resorcinarene; DMAEMA; Amphiphilic modification; Star block copolymer
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Funding
- Scientific Research Foundation of State Education Ministry in the form of the Returned Overseas Chinese Scholars
- Shanghai Leading Academic Discipline Project [B502]
- Shanghai Key Laboratory Project [08DZ2230500]
- NSERC Sentinel-Bioactive Paper Network (Canada)
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In this work, a cationic star polymer [poly(2-dimethylamino)ethyl methacrylate (PDMAEMA)] was prepared via atom transfer radical polymerization (ATRP), using brominated calix[4]resorcinarene as an initiator. Hydrophobic moieties, methyl methacrylate (MMA) and butyl acrylate (BA), were further incorporated via one-pot method. Well-defined eight-armed star block copolymers bearing hydrophilic blocks inside and hydrophobic blocks outside were synthesized. The molecular weight, particle size, electrophoretic mobility and apparent charge density were determined by gel permeation chromatography (GPC), dynamic light scattering (DLS), phase analysis light scattering (PALS) and colloidal titration, respectively. The zeta potentials and apparent charge densities of the products exhibited the characteristics of polyelectrolyte. The incorporation of hydrophobic moieties generated electrostatic screening effect. The as-synthesized amphiphilic star copolymer is promising as a thermo-sensitive gene carrier for gene therapy. (C) 2012 Elsevier B.V. All rights reserved.
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