Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 33, Issue 1, Pages 550-556Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2012.09.031
Keywords
Gold nanoparticles; Chitosan; Lipopolysaccharide; Toxicity
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Funding
- CNCSIS-UEFISCSU [509 PNII-IDEI 1996/2008]
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The impact of nanoparticles in medicine and biology has increased rapidly in recent years. Gold nanoparticles (AuNP) have advantageous properties such as chemical stability, high electron density and affinity to biomolecules. However, the effects of AuNP on human body after repeated administration are still unclear. Therefore, the purpose of the present study was to evaluate the effects of gold-11.68 nm (AuNP1, 9.8 mu g) and gold-22.22 nm (AuNP2, 19.7 mu g) nanoparticles capped with chitosan on brain and liver tissue reactivity in male Wistar rats exposed to lipopolysaccharide (LPS from Escherichia coli serotype 0111:B4, 250 mu g) upon 8 daily sessions of intraperitoneal administration. Our results suggest that the smaller size of chitosan-capped AuNP shows the protective effects against LPS-induced toxicity, suggesting a very high potential for biomedical applications. (c) 2012 Elsevier B.V. All rights reserved.
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