Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 33, Issue 8, Pages 4660-4666Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2013.07.019
Keywords
Magnetic nanoparticles; Atom transfer radical polymerization; Thermal therapy
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Funding
- National Science Foundation grant: NSF IGERT Training Grant [DGE-0653710]
- National Science Foundation grant: NSF REU Grant [EEC-1156667]
- Directorate For Engineering [1156667] Funding Source: National Science Foundation
- Div Of Engineering Education and Centers [1156667] Funding Source: National Science Foundation
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In this study, core-shell nanoparticles were developed to achieve thermal therapy that can ablate cancer cells in a remotely controlled manner. The core-shell nanoparticles were prepared using atomic transfer radical polymerization (ATRP) to coat iron oxide (Fe3O4) nanoparticles with a poly( ethylene glycol) (PEG) based polymer shell. The iron oxide core allows for the remote heating of the particles in an alternating magnetic field (AMF). The coating of iron oxide with PEG was verified through Fourier transform infrared spectroscopy and thermal gravimetric analysis. A thermoablation (55 degrees C) study was performed on A549 lung carcinoma cells exposed to nanoparticles and over a 10 min AMF exposure. The successful thermoablation of A549 demonstrates the potential use of polymer coated particles for thermal therapy. (C) 2013 Elsevier B.V. All rights reserved.
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