Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 33, Issue 8, Pages 4545-4550Publisher
ELSEVIER
DOI: 10.1016/j.msec.2013.07.011
Keywords
Gene delivery; Transfection efficiency; Poly(2-(di-methylamino)ethyl methacrylate); Biomaterials
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Funding
- Agency for Science, Technology and Research (A*STAR), Singapore, Institute of Materials Research and Engineering (IMRE)
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The synthesis and gene transfection efficiency of a series of amphiphilic copolymers with poly(dimethylaminoethyl methacrylate) (PDMAEMA), and poly(propylene glycol methacrylate) (PPGMA) segments is reported. The hydrophobic PPGMA interior allows a cell-sensitizing drug such as paclitaxel to be incorporated while the cationic and hydrophilic PDMAEMA corona allows the complexation of anionic DNA to form a nano-sized polyplex. These drug-encapsulated copolymers display excellent gene transfection efficiency as compared to PEI or PDMAEMA homopolymers. (C) 2013 Elsevier B.V. All rights reserved.
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