Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 32, Issue 6, Pages 1375-1379Publisher
ELSEVIER
DOI: 10.1016/j.msec.2012.04.017
Keywords
Solid lipid nanoparticle (SLN); Nanostructured lipid nanoparticle (NLC); High pressure homogenization (HPH); High shear homogenization (HSH); Factorial design
Categories
Funding
- FAPESP (Fundacao de Amparo a Pesquisa)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel superior)
Ask authors/readers for more resources
Solid lipid nanoparticles (SLN) and nanostructured lipid carrier (NLC) have been employed in pharmaceutics and biomedical formulations. The present study focuses on the optimization of the production process of SLN and NLC by High Shear Homogenization (HSH) and High Pressure Homogenization (HPH). To build up the surface response charts, a 2(2) full factorial design based on 2 independent variables was used to obtain an optimized formulation. The effects of the production process on the mean particle size, polydispersity index (PI) and zeta potential (ZP) were investigated. Optimized SLN were produced applying 20,000 rpm HSH and 500 bar HPH pressure and NLC process 15,000 rpm HSH and 700 bar HPH pressure, respectively. This factorial design study has proven to be a useful tool in optimizing SLN (similar to 100 nm) and NLC (similar to 300 nm) formulations. The present results highlight the benefit of applying statistical designs in the preparation of lipid nanoparticles. (C) 2012 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available