Fibrous growth of strontium substituted hydroxyapatite and its drug release

The effect of strontium on the crystallization of helical ribbon of hydroxyapatite (HAP) was investigated by single diffusion technique in silica gel matrix at 27 degrees C and physiological pH. Fibers of HAp were obtained on addition of strontium. The length of the HAp fibers, were found to decrease as the strontium substitution increases. The presence of strontium ion increased the crystallinity as well as crystallite size of HAp. The strontium substituted HAp (Sr-HAp) has similar stoichiometry to that of biological apatite. Sr-HAp was found to have increased surface area (35%) compared to control. Further, strontium substitution leads to an enhancement of in vitro bioactivity. The cumulative in-vitro amoxicillin drug release in phosphate buffer solution (PBS, pH 7.2) showed a prolonged release profile for Sr-HAp. (C) 2010 Elsevier B.V. All rights reserved.