Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 31, Issue 1, Pages 14-21Publisher
ELSEVIER
DOI: 10.1016/j.msec.2010.07.010
Keywords
Bacterial cellulose; Microbial cellulose; Vascular graft; Silicone tube; Network formation
Categories
Funding
- Swedish Research Council [621-2004-3824]
- Biosynthetic Blood Vessels [311-2006-7570]
- EU [NMP3-CT-2004-500283]
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Nanocellulose (bacterial cellulose, BC), such as that produced by Acetobacter xylinum, has shown promising results as a replacement material for small diameter vascular grafts. The surface morphology of the lumen and mechanical properties of such tubes are crucial for their performance. The growth of a BC tube in a vertical fermentation bioreactor using silicone tubing for support and as an oxygen delivery membrane has not been studied in detail previously. Oxygen concentration and the number of bacteria added influence the production of the BC tubes. A dense and smooth luminal surface was formed after 4 days on a 3 mm silicone support. The bacteria were found to be in high concentration close to the silicon support and decreased in number further away. In the region with a high bacteria concentration, dense thin layers of BC were formed since the bacteria moved close together in this region. The presented observations were summarized in a theoretical model of BC tube growth. (C) 2010 Elsevier B.V. All rights reserved.
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