Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 31, Issue 5, Pages 1091-1097Publisher
ELSEVIER
DOI: 10.1016/j.msec.2011.03.010
Keywords
Amphiphilic graft copolymer; Click chemistry; Polysulfone; Hydrophilic segments; Poly(ethylene glycol); Bio-inertness
Categories
Funding
- Istanbul Technical University
- State Planning Organization of Turkey (DPT)
- Turkish Academy of Sciences
- Research Fund
Ask authors/readers for more resources
A series of well-defined amphiphilic graft copolymers with hydrophobic polysulfone (PSU) as backbones and hydrophilic poly( ethylene glycol) (PEG) as side chains were synthesized and characterized. For this purpose, PSUs were converted to azido-functionalized polymers by successive chloromethylation and azidation processes to give clickable PSUs. Then, the (omega-hydroxyl function of the commercially available PEG-OH was converted into propargyl functionality by simple esterification process. Ultimately, the alkyne functionalized PEO was successfully grafted onto the PSUs by click chemistry. The final polymers and intermediates at various stages were characterized by H-1 NMR, FT-IR, and GPC techniques. The bioinert character of PEG grafted PSU was confirmed by static protein adsorption and prokaryotic and eukaryotic cell adhesion studies, and compared to that of unmodified PSU. (C) 2011 Elsevier By. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available