Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 31, Issue 7, Pages 1498-1504Publisher
ELSEVIER
DOI: 10.1016/j.msec.2011.06.008
Keywords
Hydroxyapatite; Porosity; Calcium phosphate cement; Scaffolds; Foaming; Bone regeneration
Categories
Funding
- European Commission [NMP3-CT-2005-013912]
- Mexican Council for Science and Technology (CONACyT)
- Generalitat de Catalunya
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Hydroxyapatite foams are potential synthetic bone grafting materials or scaffolds for bone tissue engineering. A novel method to obtain injectable hydroxyapatite foams consists in foaming the liquid phase of a calcium phosphate cement. In this process, the cement powder is incorporated into a liquid foam, which acts as a template for macroporosity. After setting, the cement hardens maintaining the macroporous structure of the foam. In this study a low molecular weight surfactant, Polysorbate 80, and a protein, gelatine, were compared as foaming agents of a calcium phosphate cement. The foamability of Polysorbate 80 was greater than that of gelatine, resulting in higher macroporosity in the set hydroxyapatite foam and higher macropore interconnectivity. Gelatine produced less interconnected foams, especially at high concentrations, due to a higher liquid foam stability. However it increased the injectability and cohesion of the foamed paste, and enhanced osteoblastic-like cell adhesion, all of them important properties for bone grafting materials. (C) 2011 Elsevier B.V. All rights reserved.
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