Journal
RESPIROLOGY
Volume 20, Issue 8, Pages 1282-1284Publisher
WILEY-BLACKWELL
DOI: 10.1111/resp.12602
Keywords
asthma; clinical allergy and immunology; clinical respiratory medicine; eosinophil; inflammation
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Severe or therapy-resistant asthma represents a major problem, and despite advanced treatment, many patients require oral corticosteroids (OCS). We aimed to determine if patients with severe asthma and elevated peripheral blood eosinophils (PBE) could have treatment with OCS adjusted using an algorithm that controlled PBE (<0.2 x 10(9)/L). In 11 patients, the OCS dose was adjusted to suppress PBE, leading to a reduced exacerbation frequency and improvement in asthma symptoms with an overall lower OCS dose.
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