Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 30, Issue 8, Pages 1204-1210Publisher
ELSEVIER
DOI: 10.1016/j.msec.2010.06.018
Keywords
Electrospinning; PLGA; Gelatin; Nanofibers; Bone tissue engineering
Categories
Funding
- Research Fund for the Doctoral Program of Higher Education [20060217012]
- Fundamental Research funds for the Central Universities [HEUCF 101003]
- National Natural Science Foundation of China [30800260]
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Electrospinning technique can be used to produce the three-dimensional nanofibrous scaffold similar to natural extracellular matrix, which satisfies particular requirements of tissue engineering scaffold. Randomly-oriented and aligned poly(lactic-co-glycolic acid) (PLGA) and PLGA/gelatin biocomposite scaffolds were successfully produced by electrospinning in the present study. The resulting nanofibrous scaffolds exhibited smooth surface and high porous structure. Blending PLGA with gelatin enhanced the hydrophilicity but decreased the average fiber diameter and the mechanical properties of the scaffolds under the same electrospinning condition. The cell culture results showed that the elongation of the osteoblast on the aligned nanofibrous scaffold was parallel to the fiber arrangement and the cell number was similar to that of randomly-oriented scaffold, indicating that the aligned nanofibrous scaffold provide a beneficial approach for the bone regeneration. (C) 2010 Elsevier B.V. All rights reserved.
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