Journal
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
Volume 29, Issue 5, Pages 1725-1731Publisher
ELSEVIER
DOI: 10.1016/j.msec.2009.01.023
Keywords
Nanofibers; Hydrophilicity; Poly(epsilon-caprolactone); Polyethylenimine; Tissue engineering
Categories
Funding
- Agricultural R&D Promotion Center [500-080142]
- Korea Science and Engineering Foundation (KOSEF)
- Ministry of Science and Technology [M1060000283-06J0000-28310]
- Korea Science and Engineering Foundation
- Korea Institute of Industrial Technology(KITECH) [2004-가-12호] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2006-0052322, 과C6A2206] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Poly(epsilon-caprolactone) (PCL) electrospun nanofibers have been reported as a scaffold for tissue engineering application. However, high hydrophobicity of PCL limits use of functional scaffold. In this Study, PCL/polyethylenimine (PEI) blend electrospun nanofibers were prepared to overcome the limitation of PCL ones because the PEI as a cationic polymer can increase cell adhesion and can improve the electrospinnability of PCL. The structure, mechanical properties and biological activity of the PCL/PEI electrospun nanofibers were studied. The diameters of the PCL/PEI nanofibers ranged from 150.4 +/- 33 to 220.4 +/- 32 nm. The PCL/PEI nanofibers showed suitable mechanical properties with adequate porosity and increased hydrophilic behavior. The cell adhesion and cell proliferation of PCL nanofibers; were increased by blending with PEI due to the hydrophilic properties of PEI. (C) 2009 Elsevier B.V. All rights reserved.
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