An enhancement on healing effect of wound dressing: Acrylic acid grafted and gamma-polyglutamic acid/chitosan immobilized polypropylene non-woven

The Wound dressing of acrylic acid-grafted and gamma-polyglutamic acid/chitosan-immobilized polypropylene non-woven fabric (PP-AAg-PGCi) was produced in this study. Gamma-polyglutamic acid (gamma-PGA) was first applied in this field to composed with chitosan. The PP-AAg-PGCi wound dressings were expected to enhance the water absorbing, water permeating and wound healing properties. The results showed that the immobilizing percentage, water absorbing value and water diffusion coefficient for PP-AAg-PGCi samples increased with the increase of the gamma-PGA in the immobilizing bath; whereas, decreased with the increase of the chitosan in the immobilizing bath, The immobilized chitosan was aggregating with the state of discontinuous and uneven mass materials on the surface of the immobilized gamma-PGA. The water absorbing, water permeating, and anti-bacterial properties of the PP-AAg-PGCi samples were much better than that of AA grafted and collagen/chitosan immobilized PP non-woven sample (PP-AAg-CCi) in our previous study. Anti-bacterial property for PP-AAg-PGCi samples was excellent. The effect on accelerating wound healing for PP-AAg-PGCi samples was strong. The product of the multi-layer material of PP-AAg-PGCi was expected to bestow better services for wound dressing. (C) 2009 Elsevier B.V. All rights reserved.