Journal
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
Volume 29, Issue 3, Pages 714-718Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2009.01.011
Keywords
Superparamagnetic; Nanoparticle; Lateral flow assay; Quantitative detection
Categories
Funding
- NSFC [20874061]
- 863 Program [2006AA03Z3591]
- Shanghai nanoproject [0652 nm012]
- SJTU [YG2007ZD04]
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The superparamagnetic nanoparticles (MNPs) with a series of sizes and magnetite contents are designed and prepared as labels used in lateral flow immunoassay (LFIA) to test if the size and magnetite content of MNPs can affect the performance of LFIA. The result showed that detection time was mainly determined by the size of MNPs, while the signal intensity was closely correlated to the magnetite content of the MNPs. In addition, the magnetic signals intensity remained stable over a long time period. Smaller MNPs with higher magnetite content are first choices as labels to construct a rapid and high-sensitive quantitative LFIA. (C) 2009 Elsevier B.V. All rights reserved.
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