Journal
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
Volume 28, Issue 1, Pages 171-178Publisher
ELSEVIER
DOI: 10.1016/j.msec.2006.11.010
Keywords
scaffolds; rapid prototyping; fused deposition modeling; micro CT; bone
Categories
Funding
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000660] Funding Source: NIH RePORTER
- NIBIB NIH HHS [R01 EB000660-02, R01 EB000660-03, R01 EB000660-02S1, R01 EB000660, R01 EB000660-04] Funding Source: Medline
Ask authors/readers for more resources
Free form fabrication and high resolution imaging techniques enable the creation of biomimetic tissue engineering scaffolds. A 3D CAD model of canine trabecular bone was produced via micro CT and exported to a fused deposition modeler, to produce polybutylene terephthalate (PBT) trabeculated scaffolds and four other scaffold groups of varying pore structures. The five scaffold groups were divided into subgroups (n=6) and compression tested at two load rates (49 N/s and 294 N/s). Two groups were soaked in a 25 degrees C saline solution for 7 days before compression testing. Micro CT was used. to compare porosity, connectivity density, and trabecular separation of each scaffold type to a canine trabecular bone sample. At 49 N/s the dry trabecular scaffolds had a compressive stiffness of 4.94 +/- 1.19 MPa, similar to the simple linear small pore scaffolds and significantly more stiff (p < 0.05) than either of the complex interconnected pore scaffolds. At 294 N/s, the compressive stiffness values for all five groups roughly doubled. Soaking in saline had an insignificant effect on stiffness. The trabecular scaffolds matched bone samples in porosity; however, achieving physiologic connectivity density and trabecular separation will require further refining of scaffold processing. (C) 2006 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available