Journal
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
Volume 28, Issue 8, Pages 1530-1543Publisher
ELSEVIER
DOI: 10.1016/j.msec.2008.04.010
Keywords
Biomolecule immobilization; Electrochemical biosensors; Conducting polymers; Review; Polymer applications; Nanocomposites
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Funding
- Foundation for Science and Technology-Portugal [PTDC/AMB/73154/2006]
- Fundação para a Ciência e a Tecnologia [PTDC/AMB/73154/2006] Funding Source: FCT
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Polymers are becoming inseparable from biomolecule immobilization strategies and biosensor platforms. Their original role as electrical insulators has been progressively substituted by their electrical conductive abilities, which opens a new and broad scope of applications. In addition, recent advances in diagnostic chips and microfluidic systems, together with the requirements of mass-production technologies, have raised the need to replace glass by polymeric materials, which are more suitable for production through simple manufacturing processes. Conducting polymers (CPs), in particular. are especially amenable for electrochemical biosensor development for providing biomolecule immobilization and for rapid electron transfer. it is expected that the combination of known polymer substrates, but also new transducing and biocompatible interfaces, with nanobiotechnological structures, like nanoparticles, carbon nanotubes (CNTs) and nanoengineered 'smart' polymers, may generate composites with new and interesting properties, providing higher sensitivity and stability of the immobilized molecules, thus constituting the basis for new and improved analytical devices for biomedical and other applications. This review covers the state-of-the-art and main novelties about the use of polymers for immobilization of biomolecules in electrochemical biosensor platforms. (c) 2008 Elsevier B.V. All rights reserved.
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