Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 218, Issue -, Pages 57-63Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2015.07.006
Keywords
Sleep apnea; Intermittent hypoxia; Atorvastatin; Toll-like receptor 4; Hippocampus; Neuroinflammation
Categories
Funding
- National Natural Science Foundation of China [81370185]
Ask authors/readers for more resources
Hippocampal neuronal damage is critical for the initiation and progression of neurocognitive impairment accompanied obstructive sleep apnea syndrome (OSAS). Toll-like receptor 4 (TLR4) plays an important role in the development of several hippocampus-related neural disorders. Atorvastatin was reported beneficially regulates TLR4. Here, we examined the effects of atorvastatin on hippocampal injury caused by chronic intermittent hypoxia (CIH), the most characteristic pathophysiological change of OSAS. Mice were exposed to intermittent hypoxia with or without atorvastatin for 4 weeks. Cell damage, the expressions of TLR4 and its two downstream factors myeloid differentiation factor 88 (MYD88) and TIR-domain-containing adapter-inducihg interferon-beta (TRW), inflammatory agents (tumor necrosis factor a and interleukin 1 beta), and the oxidative stress (superoxide dismutase and malondialdehyde) were determined. Atorvastatin decreased the neural injury and the elevation of TLR4, MyD88, TRIF, pro-inflammatory cytokines and oxidative stress caused by CIH. Our study suggests that atorvastatin may attenuate CIH induced hippocampal neuronal damage partially via TLR4 and its downstream signaling pathway. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available