Journal
MATERIALS LETTERS
Volume 117, Issue -, Pages 37-40Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2013.11.095
Keywords
Monodispersity; Magnetic materials; Biomaterials; T-Shaped microchannel reactor; Composite emulsion; Solvothermal
Funding
- Fundamental Research Funds for the Central Universities of China ministry of education [2013D110525]
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Monodisperse magnetic microspheres with biodegradability and biocompatibility were successfully prepared using a T-shaped microchannel reactor instead of the traditional three-necked flask equipped with the mechanical stirrer. Solvothermal was adopted to produce hydrophilic ferriferrous oxide (Fe3O4) nanoparticles with high magnetic responsiveness, which was subsequently emulsified with a dichloromethane solution of polylactic acid (PEA) in the presence of a gelatin stabilizer. This water-in-oil (W/O) emulsion and an additional aqueous phase, namely an aqueous polyvinyl alcohol (PVA) solution, were injected into the T-shaped microchannel reactor and converged at the joint to yield a W/O/W composite emulsion. Evaporation of the solvent in the microchannel gave rise to the target magnetic microspheres. The results show that he magnetic microspheres have a uniform particle size and good magnetic responsiveness, indicating their potential use in targeted drug delivery for cancer treatment and thermotherapy. (C) 2013 Elsevier B.V. All rights reserved
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