Preparation of antimicrobial cellulose fibers by grafting β-cyclodextrin and inclusion with antibiotics

Antimicrobial-modified cellulose fiber was prepared by covalently bonding beta-cyclodextrin (beta-CD) with cellulose fiber via citric acid (CA) and including ciprofloxacin hydrochloride (CipHCl) as antibiotics. Fourier transform infrared (FTIR) confirmed the esterification reaction between beta-cyclodextrin citrate (CA-beta-CD) and cellulose. Ungrafted cellulose fibers showed a little affinity to CipHCl, whereas beta-CD grafted fibers increased the loading amount dramatically because the equilibrium amount was more than tripled to that of ungrafted ones. Meanwhile, the release process of CipHCI from beta-CD grafted fibers was prolonged to reaches the equilibrium. The beta-CD grafted fibers loaded with CipHCl showed excellent antibacterial activity against Escherichia coli and Staphylococcus aureus, the inhibition efficiency against E. coli was higher than that against S. aureu at the same fiber content generally. (C) 2014 Elsevier B.V. All rights reserved.