Journal
MATERIALS LETTERS
Volume 132, Issue -, Pages 59-62Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2014.06.038
Keywords
Vascular grafts; Wet-spun; Oriented microfiber scaffold; Smooth muscle cells; Cell infiltration
Funding
- National Natural Science Foundation of China [51173084]
- Tianjin Research Program of Application Foundation and Advanced Technology [13JCY8JC25200]
- National Program on Key Basic Research Project (973 Program) [2011CB606202]
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The tissue engineered blood vessel requires oriented fibrous scaffold as template to guide smooth muscle cells (SMCs) oriented growth and infiltration. It is a considerable challenge to fabricate this kind of fibrous scaffold. In this letter, we developed a new wet-spinning system that involves a blended solution of edible oil and hexane as a non-solvent coagulation bath to fabricate oriented poly(epsilon-caprolactone) (PCL) microfiber scaffold. The fiber diameter and porosity could be controlled in the range of 7 to 27 mu m and 68 to 82%, respectively. SMCs could grow in an oriented fashion along the fibers and infiltrate inside the scaffold as well as maintain SMCs phenotype. This oriented microfiber scaffold has a promising potential for regenerating blood vessels and other fibrous tissues such as tendon, ligament and intervertebral discs. (C) 2014 Elsevier B.V. All rights reserved.
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