Journal
MATERIALS LETTERS
Volume 137, Issue -, Pages 393-397Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2014.09.045
Keywords
Gradients; Electrospinning; Nanofibrous scaffolds; Biomaterials; Nanocomposites
Funding
- National Natural Science Foundation of China [51105298, 51422508]
- Research Fund for the Doctoral Program of Higher Education [20110201120027]
- Fundamental Research Funds for Central Universities of China
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One of the major challenges in tissue engineering is to engineer biomaterial scaffolds with desirable gradients for the regeneration of composite tissues. Here we propose a unique electrospinning strategy to fabricate nanofibrous scaffolds with both structure and material composition gradients. The results demonstrate that the microstructural organization of nanofibers gradually changed from random to aligned patterns. Nanoparticles like nanohydroxyapatite (nano-HA) were encapsulated into these nanofibers and nano-HA content in the electrospun scaffolds gradually altered in a similar gradient manner to structural organization. This simple yet versatile method might be useful to engineer graded tissues by flexibly generating tissue-specific structure and material gradients. (c) 2014 Elsevier B.V. All rights reserved.
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