Journal
MATERIALS LETTERS
Volume 92, Issue -, Pages 25-28Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2012.10.077
Keywords
Porous materials; Nanocomposites; Cell adhesion; Flocculent mineral accretions
Funding
- Independent Innovation Foundation of Huazhong University of Science and Technology [2010JCO29/2011JC042]
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A well-developed three-dimensional (3-D) biphasic calcium phosphate (BCP) scaffold with inter-connectivity and high porosity was fabricated for bone tissue engineering. After being coated with hydroxyapatite/poly-t-lactide (HA/PLLA) nanocomposites, the scaffold maintained the framework structure, and the porous network structure of scaffolds remained unchanged. MTT assay showed significantly increased proliferation of human bone mesenchymal stem cells (hBMSCs) on coated BCP scaffolds compared with uncoated scaffolds 5 days after seeding (p <0.05). Under scanning electron microscopy, hBMSCs on the coated BCP scaffolds showed more spreading on the first day after seeding. Furthermore, flocculent mineral accretions were formed on the surface of HA/PLLA coating. Cell adherence and proliferation ability of hBMSCs on scaffolds were improved by coating with HA/PLLA nanocomposites. (C) 2012 Elsevier B.V. All rights reserved.
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