Journal
MATERIALS LETTERS
Volume 93, Issue -, Pages 157-160Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2012.11.036
Keywords
Tissue engineering; Gas foaming; Tubular porosity; Fiber leaching; Poly(epsilon-caprolactone)
Funding
- Italian Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR) [RBPR05JH2P ITALNANONET]
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The aim of this study was to engineer a scaffold for tissue engineering with double shape pore architecture, with tubular and isotropic pores. A novel method is herein proposed, based on the combination of gas foaming and fiber templating. In particular, the tubular pores have been obtained by leaching of melt-spun saccharide fibers (cotton candy) within CO2-foamed poly(epsilon-caprolactone). The optimization of the scaffold has been conducted via the selection of the proper saccharide, its thermal treatment to stabilize the spun fiber (crystallization), the formation of the polymer-fiber composite, the selection of the proper gas-foaming processing parameter and the final leaching in water. (C) 2012 Elsevier B.V. All rights reserved.
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