Journal
MATERIALS LETTERS
Volume 70, Issue -, Pages 76-79Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2011.11.093
Keywords
Hydroxyapatite; Strontium substitution; Fiber technology; Bioceramics; Cytocompatibility; Mechanical reinforcement
Funding
- K.C. Wong Education Foundation
- Natural Science Foundation of China [81171458, 81150007]
- Science and Technology Commission of Shanghai Municipality [08411950600]
- Shanghai Municipal Education Commission [12YZ039]
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The strontium substituted hydroxyapatite (SrHA) whiskers with 6.6 mol% of Ca replaced by Sr were successfully synthesized via homogeneous precipitation method. The product had a width of 0.2-8 mu m and length up to 155 pm. The human osteoblast-like cell (MG-63) culture showed that Sr substitution could stimulate the proliferation of MG-63 at certain extracted concentrations. Furthermore, the addition of SrHA whiskers could significantly improve the mechanical properties of calcium phosphate cement (CPC). The 5 wt.% SrHA whisker reinforced CPC revealed the highest compressive strength of 2.92 MPa, which was almost 2-times higher than that of the pure CPC. Our study indicated that SrHA whisker might be a potential candidate as a new bioactive and mechanical reinforcement material for hard tissue regeneration applications. (C) 2011 Elsevier B.V. All rights reserved.
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