Journal
MATERIALS LETTERS
Volume 73, Issue -, Pages 119-122Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2011.12.107
Keywords
Composite materials; Ceramics; Polymers
Funding
- Dankook University
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Here we produced a novel nano-composite scaffold made of chitosan (Chit) and nanobioactive glass (nBG) retaining dual-pore structure through the robocasting technique. Robotic-dispensed composite solution (Chit with 10 wt% nBG) was rapidly solidified under a dry-ice cooled bath, which was subsequently freeze-dried. The scaffold featured the pre-designed macrochanneled (hundreds of micrometers) pore configuration and contained well-developed micropores (a few to 10 mu m in size) throughout the framework. The addition of nBG facilitated rapid induction of bone mineral-like apatite in a simulated body fluid, demonstrating in vitro bone-bioactivity. On the dual-pore structured scaffolds, bone cells presented good adherence and active growth with culture time. The developed Chit/nBG scaffolds may find potential usefulness as bone tissue engineering matrices. (C) 2011 Elsevier B.V. All rights reserved.
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