Hollow microspheres fabricated from instant adhesive

Non-invasive surgery techniques and drug delivery system with acoustic characteristics of ultrasound contrast agent have been studied intensively in recent years. Many ultrasound contrast agents are commercially available, and they are usually composed of a microbubble coated by a surfactant or lipid bilayer, i.e., a hollow microsphere. We show that the hollow microsphere with polymer shell can be fabricated just blowing vapor of commonly-used instant adhesive into water as microbubbles. The hollow microspheres are composed of cyanoacrylate, a biocompatible material used for adhesion to human tissue such as skin, blood vessels, and organs. Moreover these are less than 10 gm in diameter, which is smaller than a blood capillary (approximately 10 virn). Therefore, with their stable polymer shells, the hollow microspheres are possible ultrasound contrast agents, and are expected to be generated at low cost on the medical frontline, and not in a pharmaceutical factory. (C) 2011 Elsevier B.V. All rights reserved.