Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 41, Issue 11, Pages 8257-8267Publisher
SPRINGER
DOI: 10.1007/s11164-014-1889-x
Keywords
Biscoumarin; Dihydropyran; Staphylococcus aureus; Minimum inhibitory concentration
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Funding
- Industrial Research Project of Science and Technology Department of Shaanxi Province [2013K09-25]
- National Natural Science Foundation of China [81001460, 81273555]
- Innovation Plan of Science and Technology of Shaanxi Province [2014KTCL03-03]
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In an attempt to find a new class of antimicrobial agents, a series of biscoumarin (1-4) and dihydropyran (5 and 6) derivatives were prepared. These compounds were screened for their in vitro antibacterial activity against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC). There are two classical intramolecular O-H center dot center dot center dot O hydrogen bonds (HBs) in the structures of biscoumarins 1-4 and the corresponding total HB energy were further performed with the density functional theory (DFT) [B3LYP/6-31G*] method.
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