Journal
MATERIALS LETTERS
Volume 65, Issue 13, Pages 2079-2082Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2011.04.013
Keywords
Biphasic scaffold; Bioactivity glass; Collagen; Chitosan; Adhesion; Ceramics
Funding
- National Science Foundation of China [30901532]
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A biphasic scaffold with a stratified structure for osteochondral tissue engineering was developed. The chondral phase was a collagen-chitosan composite. The osseous phase was a composite of bioactive glass and collagen. Collagen integrated in the two respective phases was connected by cross-linking agents. Both layers of the scaffold showed interconnected porous structures. After being immersed into stimulated body fluid, precipitation of spherulitic grains could be found on the surface of the osseous phase and this precipitation was proved to be hydroxyapatite by X-ray diffraction and Fourier transform infrared spectroscopy. Inversion, fluorescence and scanning electron microscopy further confirmed that bone marrow stromal cells could anchor on this scaffold with healthy spreading. As the consequence, this biphasic scaffold may have significant potential as an alternative for osteochondral tissue engineering. (C) 2011 Elsevier B.V. All rights reserved.
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