Fabrication of a novel micro-nano fibrous nonwoven scaffold with Antheraea assama silk fibroin for use in tissue engineering

The success of developing artificial organs by tissue engineering depends on scaffold properties and architecture. Here, we describe the fabrication of an Antheraea assama fibroin based novel micro-nano fibrous nonwoven scaffold. The morphological and chemical characterization was done by scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR) respectively, which demonstrated the formation of scaffold with micro-nano architecture. The biocompatibility was assessed in vitro by haemolysis and cytotoxicity assays, whereby the scaffold was found to be nontoxic and efficient in supporting cell adhesion and growth. (C) 2009 Elsevier B.V. All rights reserved.