Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 42, Issue 4, Pages 3105-3116Publisher
SPRINGER
DOI: 10.1007/s11164-015-2200-5
Keywords
Triazole Schiff base; 1-[Bi-(4-fluorophenyl)methyl]piperazine; Microwave irradiation; Antitumor activity
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Funding
- Fundamental Research Funds for the Central Universities, Southwest University for Nationalities [12NZYTH03]
- Sichuan Provincial Department of science and technology support program [2015NZ0033]
- Postgraduate Degree Construction Project of Southwest University for Nationalities [2014XWD-S0703]
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Fourteen novel 1,2,4-triazole Schiff bases containing the 1-[bi-(4-fluorophenyl)methyl]piperazine group were prepared, in good yield (73-85 %), in five steps starting from 1-[bi-(4-fluorophenyl)methyl]piperazine and ethyl chloroacetate, with use of microwave irradiation. The structures of the new compounds were characterized by IR spectroscopy, MS, H-1 and C-13 NMR spectroscopy, and elemental analysis. Assay of the newly prepared compounds for bioactivity against tumor cells revealed that the most of the compounds had good to excellent inhibitory activity against CDC25B (99.70 % inhibition). The 4-amino-5-[4-bi-(4-fluorophenyl) methylpiperazin-1-ylmethyl]-1,2,4-triazole-3-thione group was found to be beneficial group improving anti-tumor activity to some extent.
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