Journal
APPLIED SURFACE SCIENCE
Volume 355, Issue -, Pages 32-44Publisher
ELSEVIER
DOI: 10.1016/j.apsusc.2015.07.064
Keywords
Biomedical implants; Titanium-silver coatings; Antibacterial activity; Osseointegration ability; Magnetron sputtering
Categories
Funding
- National Natural Science Foundation of China [31400815]
- Foundation for the Author of National Excellent Doctoral Dissertation of PR China (FANEDD) [201483]
- National High Technology Research and Development Program (863Program) of China [SS2015AA020921]
- State Key Laboratory of Military Stomatology [2014KB03]
- City University of Hong Kong Strategic Research Grant (SRG) [7004188]
- Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [112212]
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Bacterial infection and loosing are serious complications for biomedical implants in the orthopedic, dental, and other biomedical fields and the ideal implants should combine good antibacterial ability and bioactivity. In this study, nanostructured titanium-silver (Ti-Ag) coatings with different Ag contents (1.2 to 21.6 at%) are prepared on Ti substrates by magnetron sputtering. As the Ag concentration is increased, the coatings change from having dense columnar crystals to sparse ones and eventually no columnar structure. The Ti-Ag coatings can effectively kill Staphylococcus aureus during the first few days and remain moderately antibacterial after immersion for 75 days. Compared to pure Ti, the Ti-Ag coatings show good cytocompatibility as indicated by good osteoblast adhesion, proliferation, intracellular total protein synthesis, and alkaline phosphatase (ALP) activity. In addition, cell spreading, collagen secretion, and extracellular matrix mineralization are promoted on the coatings with the proper Ag contents due to the nanostructured morphological features. Our results indicate that favorable antibacterial activity and osseointegration ability can be simultaneously achieved by regulating the Ag contents in Ti-Ag coatings. (C) 2015 Elsevier B.V. All rights reserved.
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