Journal
RESEARCH IN VETERINARY SCIENCE
Volume 103, Issue -, Pages 28-33Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2015.09.009
Keywords
(+)-Catechin; Transmissible gastroenteritis coronavirus (TGEV); Antiviral; Antioxidation
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Funding
- planning innovation project of S&T in Shaanxi Province [2014KTCQ02-02]
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Transmissible gastroenteritis virus (TGEV) causes transmissible gastroenteritis (TGE), especially in newborn piglets, which severely threatens the worldwide pig industry. In this study, (+)-catechin was evaluated for its antiviral effect against TGEV in vitro. Viability assays revealed that (+)-catechin treatment exerted a dose-dependent rescue effect in TGEV-infected ST cells, and this result was only obtained with the post-treatment application of ()-catechin. The viral yields in ( +)-catechin-treated cultures were reduced by almost three log(10) units. Quantitative real-time PCR analysis of the TGEV genome revealed that TGEV RNA replication was restricted after ( +)catechin treatment. Intracellular reactive oxygen species (ROS) detection showed that ( +)-catechin alleviated ROS conditions induced by TGEV infection. Our results showed that ( +)-catechin exerts an inhibitory effect on TGEV proliferation in vitro and is involved its antioxidation. (C) 2015 Elsevier Ltd. All rights reserved.
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