Journal
RESEARCH IN VETERINARY SCIENCE
Volume 102, Issue -, Pages 196-199Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2015.08.016
Keywords
Adipose tissue; Cow; NGF; BDNF; Receptors; Expression
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Funding
- Italian Ministry of Education, University and Research [GEN2PHEN]
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Currently, there are no reports of neurotrophins in adipose tissue of cows. The distribution of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and their high-affinity tyrosine kinase receptors TrkA and TrkB, was investigated by irnmunohistochemical method in the subcutaneous adipose tissue of cow at mid-lactation. Results revealed the localization of NGF and BDNF along the plasma membrane and cytoplasm of adipocytes. Neurotrophin receptors TrkA and TrkB showed moderate and strong positive staining in adipocytes, respectively. The expression of NGF, BDNF, TRKB but not of TRKA was also confirmed at transcriptional level by RT-PCR analyses. Considering the involvement of BDNF on fat metabolism and of NGF on activation of the sympathetic response in human and rodents, these neurotrophins could be related to lipogenesis and lipolysis occurring during lactation in cows. The local production of these neurotrophins supports their potential paracrine function for the regulation of adipocyte activity and deserve further investigations. (C) 2015 Published by Elsevier Ltd.
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