Journal
REPRODUCTIVE TOXICOLOGY
Volume 54, Issue -, Pages 26-36Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2014.12.002
Keywords
Perfluorooctanoic acid; Mammary gland; Puberty; CD-1; C57Bl/6; Vaginal opening; Estrous cycle
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Funding
- National Toxicology Program, National Institute of Environmental Health Sciences, NIH
- Intramural Research Training Award
- NIEHS
- NIH
- Curriculum of Toxicology at UNC Chapel Hill, Chapel Hill, NC, USA
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Perfluorooctanoic acid (PFOA) is a developmental toxicant in mice, with varied strain outcomes depending on dose and period of exposure. The impact of PFOA on female mouse pubertal development at low doses (<= 1 mg/kg) has yet to be determined. Therefore, female offspring from CD-1 and C57Bl/6 dams exposed to PFOA, creating serum concentrations similar to humans, were examined for pubertal onset, including mammary gland development. Pups demonstrated a shorter PFOA elimination half-life than that reported for adult mice. Prenatal exposure to PFOA caused significant mammary developmental delays in female offspring in both strains. Delays started during puberty and persisted into young adulthood; severity was dose-dependent. Also an evaluation of female serum hormone levels and pubertal timing onset revealed no effects of PFOA compared to controls in either strain. These data suggest that the mammary gland is more sensitive to early low level PFOA exposures compared to other pubertal endpoints, regardless of strain. Published by Elsevier Inc.
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