Journal
REPRODUCTIVE TOXICOLOGY
Volume 56, Issue -, Pages 118-140Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2015.05.015
Keywords
Nanoparticles; Nanomaterial; Ultrafine particles; Developmental toxicity; Reproductive toxicity; Inhalation; Instillation; Pregnancy
Categories
Funding
- Risks of Nanotechnology Knowledge and Information Center (KIR nano) in the Netherlands
- Italian national project Impact of engineered nanoparticles on reproductive health - Italian Ministry of Health [RF-2009-1536665]
- Italian national project Impact of engineered nanoparticles on reproductive health - COST Action MODENA
- FP7 Project NanoReg [310584]
- FP7 Project MARINA [263215]
- Danish Center for Nanosafety grant from the Danish Working Environment Research Foundation [20110092173-3]
- French National Research Agency project EPAPP Effects of atmospheric pollution on placental function an post-natal development [ANR-13-CESA-0011]
- European Research Council [311765]
- European Research Council (ERC) [311765] Funding Source: European Research Council (ERC)
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This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo-fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis. (C) 2015 The Authors. Published by Elsevier Inc.
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