Journal
REPRODUCTIVE TOXICOLOGY
Volume 53, Issue -, Pages 75-81Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2015.04.002
Keywords
Azo dye; Reproductive tract male; Environmental exposure; Fertility
Categories
Funding
- FAPESP [08/10449-7]
- PLISSER (Programa Latinoamericano de Salud Sexual y Reproductiva)
- CAPES
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [08/10449-7] Funding Source: FAPESP
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Disperse Red 1 (DR1), which is widely used in the textile industry, is an azo dye that contributes to the toxicity and pollution of wastewater. To assess the toxic effects of DR1 on reproduction, sexually mature male mice (Mus musculus, strain CF-1) were orally (gavage) treated with single doses of the compound at 20, 100 and 500 mg/kg body weight. Testicular features and sperm parameters were evaluated 8.3, 16.6 and 24.9 days after treatments. In addition to testicular toxicity caused by the dye, the data clearly showed an increased frequency of sperm with abnormal morphology and decreased fertility. An increased amount of DNA damage was also detected in testis cells 16.6 and 24.9 days after treatments with 100 and 500 mg/kg. This study demonstrated the toxic and genotoxic effects of DR1, indicating the harmful activity of this dye on reproductive health. (C) 2015 Elsevier Inc. All rights reserved.
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