Journal
REPRODUCTIVE TOXICOLOGY
Volume 57, Issue -, Pages 165-175Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2015.07.072
Keywords
Polymeric nanoparticles; PEG-b-PLA; Endocrine disruptors; Reproductive toxicity; Nanotoxicology; Estrous cycle; Pituitary; Progesterone
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Funding
- Grant Agency for Support of Science and Research (APVV) [APVV 0404-11]
- VEGA [2/0172/14]
- Intramural Grant of Slovak Medical University Bratislava [16]
- realization of the project Center of excellence of environmental health from European Regional Development Fund [26240120033]
- project of EC FC7 [INFRA-2010-1.131, 262,163]
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We studied delayed effects of neonatal exposure to polymeric nanoparticle poly(ethylene glycol)-block-polylactide methyl ether (PEG-b-PLA) on the endpoints related to pubertal development and reproductive function in female Wistar rats from postnatal day 4 (PND4) to PND 176. Female pups were injected intraperitoneally, daily, from PND4 to PND7 with PEG-b-PLA (20 or 40 mg/kg b.w.). Both doses of PEG-b-PLA accelerated the onset of vaginal opening compared with the control group. In the low-dose PEG-b-PLA-treated group, a significantly reduced number of regular estrous cycles, increased pituitary weight due to hyperemia, vascular dilatation and congestion, altered course of hypothalamic gonadotropin-releasing hormone-stimulated luteinizing hormone secretion, and increased progesterone serum levels were observed. The obtained data indicate that neonatal exposure to PEG-b-PLA might affect the development and function of hypothalamic-pituitary-ovarian axis (HPO), and thereby alter functions of the reproductive system in adult female rats. Our study indicates a possible neuroendocrine disrupting effect of PEG-b-PLA nanoparticles. (C) 2015 Elsevier Inc. All rights reserved.
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